PARAMETERS

USP 25

SPECIFICATION

RESULT

REMARKS

Description

Tasteless, odourless, white to off-white, coarse to fine powder

Solubility

Swells in water, producing, when dispersed, a white, opaque dispersion or gel. Insoluble in organic solvents and in dilute acids

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Identification

A: Mix 6 g with 300 ml in a blender at 18000 rpm for 5 minutes: a white, opaque, dispersion is produced which does not settle on standing

B: Add several drops of the dispersion obtained in ID??to a solution of aluminum chloride (1 in10) : each drop forms a white, opaque globule which does not disperse on standing .

C: Add 3 ml of iodine TS to the dispersion obtained in ID?? : no blue or purplish blue colour is produced

Viscosity <911>

pH <791>

Between 6.0 and 8.0, determined on the dispersion prepared in the test for Viscosity

Loss on drying

Dry it at 105? to constant weight: it loses not 0more than 8.0% of its weight

Residue on ignition <281>

Not more than 5.0%

Heavy metals <231>

Not more than 0.001%

Organic volatile substances <467>

Meets the requirements

Assay for carboxymethyl cellulose

Not less than 75% and not more than 125% of the labeled amount calculated on dry basis